Version 5.4
Homo sapiens Gene: SEC62
Summary
InnateDB Gene IDBG-64313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC62
Gene Name SEC62 homolog (S. cerevisiae)
Synonyms Dtrp1; HTP1; TLOC1; TP-1
Species Homo sapiens
Ensembl Gene ENSG00000008952
Encoded Proteins
IDBP-64315
SEC62 homolog (S. cerevisiae)
IDBP-479596
SEC62 homolog (S. cerevisiae)
IDBP-480200
SEC62 homolog (S. cerevisiae)
IDBP-474745
SEC62 homolog (S. cerevisiae)
IDBP-484628
SEC62 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:169966635-169998373
Strand Forward strand
Band q26.2
Transcripts
ENST00000337002 ENSP00000337688
ENST00000461933
ENST00000460513 ENSP00000419319
ENST00000480708 ENSP00000420331
ENST00000487736 ENSP00000420304
ENST00000469515 ENSP00000418342
ENST00000481435
ENST00000497277
ENST00000469890
ENST00000470355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005524 ATP binding
GO:0008565 protein transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0006810 transport
GO:0015031 protein transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027706
View Gene Order
ENSBTAG00000039442
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03060
Protein export pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592561 Hs.593127 Hs.629470 Hs.713245 Hs.742142
RefSeq NM_003262
HUGO
OMIM
CCDS CCDS3210
HPRD 03706
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca