InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDB1

Summary

InnateDB Gene

IDBG-643391.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDB1

Gene Name

DNA damage-binding protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021569

Encoded Proteins

IDBP-695954

DNA damage-binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167986:
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:40509559-40537404

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028740

ENSBTAP00000028740

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 206 interaction(s) predicted by orthology.

Predicted by orthology
Total	206 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070914	UV-damage excision repair
GO:1901990	regulation of mitotic cell cycle phase transition

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex
GO:0070062	extracellular vesicular exosome
GO:0080008	Cul4-RING E3 ubiquitin ligase complex