InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NDUFS1

Summary

InnateDB Gene

IDBG-643401.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFS1

Gene Name

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021976

Encoded Proteins

IDBP-695964

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023228:
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:94893227-94922667

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029301

ENSBTAP00000029301

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0042773	ATP synthesis coupled electron transport
GO:0045333	cellular respiration
GO:0046034	ATP metabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0005758	mitochondrial intermembrane space
GO:0016020	membrane
GO:0070469	respiratory chain