Version 5.4
Bos taurus Gene: BT.87657
Summary
InnateDB Gene IDBG-643499.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.87657
Gene Name alpha-2-macroglobulin receptor-associated protein precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000073
Encoded Proteins
IDBP-696054
alpha-2-macroglobulin receptor-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163956:
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:107207883-107221544
Strand Forward strand
Band
Transcripts
ENSBTAT00000000081 ENSBTAP00000000081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0048019 receptor antagonist activity
GO:0050750 low-density lipoprotein particle receptor binding
GO:0070326 very-low-density lipoprotein particle receptor binding
Biological Process
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0032091 negative regulation of protein binding
GO:1900116 extracellular negative regulation of signal transduction
GO:1900222 negative regulation of beta-amyloid clearance
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163956
View Gene Order
ENSMUSG00000029103
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
reelinpathway
Reelin signaling pathway
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL F6RBT3
UniProt Splice Variant
Entrez Gene 504957
UniGene Bt.2982
RefSeq NM_001080225
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018454 DAAA02018455
GenPept
RNA Seq Atlas 504957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca