Version 5.4
Bos taurus Gene: SH3BP2
Summary
InnateDB Gene IDBG-643685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BP2
Gene Name SH3 domain-binding protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013996
Encoded Proteins
IDBP-696275
SH3-domain binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087266:
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:108023960-108034231
Strand Forward strand
Band
Transcripts
ENSBTAT00000018600 ENSBTAP00000018600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000087266
View Gene Order
ENSMUSG00000054520
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.21789
RefSeq NM_001191526 XM_005208259
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca