Version 5.4
| Bos taurus Gene: PRKAR1A | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-643694.3 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | PRKAR1A | ||||||||||||||||||||||
| Gene Name | cAMP-dependent protein kinase type I-alpha regulatory subunit | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000008621 | ||||||||||||||||||||||
| Encoded Proteins |
cAMP-dependent protein kinase type I-alpha regulatory subunit
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108946:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 19:62317497-62328889 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | |||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
DAP12 interactions pathway
Aquaporin-mediated transport pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Regulation of insulin secretion pathway
Factors involved in megakaryocyte development and platelet production pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
DARPP-32 events pathway
Calmodulin induced events pathway
DAG and IP3 signaling pathway
PLC-gamma1 signalling pathway
Signaling by FGFR pathway
Hemostasis pathway
Immune System pathway
Integration of energy metabolism pathway
EGFR interacts with phospholipase C-gamma pathway
Transmembrane transport of small molecules pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
NGF signalling via TRKA from the plasma membrane pathway
PLC beta mediated events pathway
Downstream signaling of activated FGFR pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Signalling by NGF pathway
PKA activation pathway
Signaling by Hedgehog pathway
Phospholipase C-mediated cascade pathway
PKA activation in glucagon signalling pathway
Downstream signal transduction pathway
Opioid Signalling pathway
Glucagon signaling in metabolic regulation pathway
Innate Immune System pathway
Ca-dependent events pathway
CaM pathway pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
FSH pathway
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| REACTOME |
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Metabolism pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
Hemostasis pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Integration of energy metabolism pathway
Ca-dependent events pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
Metabolism pathway
PKA activation in glucagon signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Aquaporin-mediated transport pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Signaling by EGFR pathway
Phospholipase C-mediated cascade pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
Signaling by Hedgehog pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
PKA activation pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Apoptosis pathway
Insulin signaling pathway pathway
Insulin signaling pathway pathway
Apoptosis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Alpha4 beta1 integrin signaling events
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Bt.10903 | ||||||||||||||||||||||
| RefSeq | NM_001076358 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||