InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FGFR3

Summary

InnateDB Gene

IDBG-643902.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGFR3

Gene Name

fibroblast growth factor receptor 3 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007164

Encoded Proteins

IDBP-696506

fibroblast growth factor receptor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068078:
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:109691052-109704277

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009427

ENSBTAP00000009427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001501	skeletal system development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002009	morphogenesis of an epithelium
GO:0002089	lens morphogenesis in camera-type eye
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010518	positive regulation of phospholipase activity
GO:0014003	oligodendrocyte development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021762	substantia nigra development
GO:0022010	central nervous system myelination
GO:0030154	cell differentiation
GO:0030900	forebrain development
GO:0031398	positive regulation of protein ubiquitination
GO:0035019	somatic stem cell maintenance
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410	positive regulation of MAPK cascade
GO:0043525	positive regulation of neuron apoptotic process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045597	positive regulation of cell differentiation
GO:0045839	negative regulation of mitosis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046777	protein autophosphorylation
GO:0048546	digestive tract morphogenesis
GO:0048678	response to axon injury
GO:0048712	negative regulation of astrocyte differentiation
GO:0048839	inner ear development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216	cartilage development
GO:0060113	inner ear receptor cell differentiation
GO:0060349	bone morphogenesis
GO:0060385	axonogenesis involved in innervation
GO:0061144	alveolar secondary septum development
GO:0070307	lens fiber cell development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072148	epithelial cell fate commitment
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102	cochlea development
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902178	fibroblast growth factor receptor apoptotic signaling pathway

Cellular Component

GO:0005764	lysosome
GO:0005887	integral component of plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm