Version 5.4
Bos taurus Gene: NRXN2
Summary
InnateDB Gene IDBG-643962.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRXN2
Gene Name neurexin-2-beta precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000244
Encoded Proteins
IDBP-696565
neurexin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110076:
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:43476403-43576128
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000307 ENSBTAP00000000307
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007416 synapse assembly
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0042297 vocal learning
GO:0071625 vocalization behavior
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110076
View Gene Order
ENSMUSG00000033768
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BFN9
UniProt Splice Variant
Entrez Gene 537808
UniGene Bt.9366
RefSeq NM_001192922 XM_005227132 XM_005227134 XM_005227140 XM_005227142 XM_005227143 XM_005227144 XM_005227145 XM_005227146
HUGO HGNC:8009
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063536 DAAA02063537 DAAA02063538
GenPept
RNA Seq Atlas 537808

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca