InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LONP1

Summary

InnateDB Gene

IDBG-644070.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LONP1

Gene Name

Lon protease homolog, mitochondrial

Synonyms

PRSS15

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001795

Encoded Proteins

IDBP-696678

lon protease homolog, mitochondrial precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196365:
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19814902-19833230

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002350

ENSBTAP00000002350

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003727	single-stranded RNA binding
GO:0004176	ATP-dependent peptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043531	ADP binding
GO:0043565	sequence-specific DNA binding
GO:0051880	G-quadruplex DNA binding
GO:0070182	DNA polymerase binding
GO:0070361	mitochondrial light strand promoter anti-sense binding
GO:0070362	mitochondrial heavy strand promoter anti-sense binding

Biological Process

GO:0001666	response to hypoxia
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006508	proteolysis
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0007005	mitochondrion organization
GO:0019941	modification-dependent protein catabolic process
GO:0030163	protein catabolic process
GO:0034599	cellular response to oxidative stress
GO:0051131	chaperone-mediated protein complex assembly
GO:0051260	protein homooligomerization
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0070407	oxidation-dependent protein catabolic process
GO:0090296	regulation of mitochondrial DNA replication

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000196365

View Gene Order

ENSMUSG00000041168

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.43820

RefSeq

NM_001015569

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas