InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.106000

Summary

InnateDB Gene

IDBG-644089.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.106000

Gene Name

scaffold attachment factor B1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007875

Encoded Proteins

IDBP-696704

scaffold attachment factor B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160633:
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a \'transcriptosome complex\' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19846208-19876661

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002344

ENSBTAP00000002344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding

Biological Process

Cellular Component

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000160633

View Gene Order

ENSMUSG00000071054

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

Cross-References

SwissProt

TrEMBL

E1B9I2

UniProt Splice Variant

Entrez Gene

539785

UniGene

Bt.106000

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02019576 DAAA02019577 DAAA02019578 DAAA02019579

GenPept

RNA Seq Atlas

539785