Version 5.4
Bos taurus Gene: PTPRS
Summary
InnateDB Gene IDBG-644158.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRS
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018052
Encoded Proteins
IDBP-696811
protein tyrosine phosphatase, receptor type, S
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105426:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:20191965-20256722
Strand Forward strand
Band
Transcripts
ENSBTAT00000044949 ENSBTAP00000042388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0021510 spinal cord development
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0022038 corpus callosum development
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105426
View Gene Order
ENSMUSG00000013236
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196606
ECM proteoglycans pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BIU8
UniProt Splice Variant
Entrez Gene 537480
UniGene Bt.106269 Bt.9933
RefSeq XM_002688919 XM_005198951
HUGO HGNC:9681
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019588
GenPept
RNA Seq Atlas 537480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca