Bos taurus Gene: COL4A4

Summary
InnateDB Gene IDBG-644214.2
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol COL4A4
Gene Name Collagen alpha-4(IV) chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021310
Encoded Proteins
IDBP-696849 collagen, type IV, alpha 4
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081052:
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 115971118-116104632
Strand Reverse strand
Band 0
Transcripts
ENSBTAT00000018302  ENSBTAP00000018302
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005201 extracellular matrix structural constituent
Biological Process
GO:0032836 glomerular basement membrane development
Cellular Component
GO:0005581 collagen
GO:0005587 collagen type IV
GO:0005604 basement membrane
GO:0005605 basal lamina
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSG00000081052 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSMUSG00000067158 Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121139 Collagen biosynthesis and modifying enzymes
KEGG
hsa05146  Amoebiasis
hsa04512  ECM-receptor interaction
hsa04510  Focal adhesion
hsa05200  Pathways in cancer
hsa04974  Protein digestion and absorption
hsa05222  Small cell lung cancer
INOH
INOH website Integrin signaling pathway
PID BIOCARTA
100122 Intrinsic prothrombin activation pathway [Biocarta view]
100072 Platelet amyloid precursor protein pathway [Biocarta view]
100089 Regulators of bone mineralization [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F1MJ71
UniProt Splice Variant
Entrez Gene 407107 
UniGene
RefSeq XM_003585388 
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006104 DAAA02006105 DAAA02006106 DAAA02006107 DAAA02006108 DAAA02006109 DAAA02006110 DAAA02006111 DAAA02006112
GenPept
ImmGen COL4A4 (murine) 
RNA Seq Atlas 407107