Bos taurus Gene: COL4A4
Summary
InnateDB Gene IDBG-644214.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL4A4
Gene Name Collagen alpha-4(IV) chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021310
Encoded Proteins
collagen, type IV, alpha 4
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081052:
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq, Jul 2008]
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3\' UTR. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:115971118-116104632
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018302 ENSBTAP00000018302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
Biological Process
GO:0032836 glomerular basement membrane development
Cellular Component
GO:0005581 collagen trimer
GO:0005587 collagen type IV trimer
GO:0005604 basement membrane
GO:0005605 basal lamina
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
NCAM signaling for neurite out-growth pathway
Degradation of the extracellular matrix pathway
NCAM1 interactions pathway
Axon guidance pathway
Signal Transduction pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen degradation pathway
Signaling by PDGF pathway
Collagen formation pathway
Anchoring fibril formation pathway
Collagen formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
NCAM1 interactions pathway
Collagen biosynthesis and modifying enzymes pathway
Anchoring fibril formation pathway
Extracellular matrix organization pathway
Laminin interactions pathway
Axon guidance pathway
Integrin cell surface interactions pathway
Signaling by PDGF pathway
Developmental Biology pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Signal Transduction pathway
NCAM signaling for neurite out-growth pathway
Degradation of the extracellular matrix pathway
Collagen degradation pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Protein digestion and absorption pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
Focal adhesion pathway
ECM-receptor interaction pathway
Protein digestion and absorption pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Platelet amyloid precursor protein pathway [Biocarta view]
Regulators of bone mineralization [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F1MJ71
UniProt Splice Variant
Entrez Gene 407107
UniGene
RefSeq
HUGO HGNC:2206
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006104 DAAA02006105 DAAA02006106 DAAA02006107 DAAA02006108 DAAA02006109 DAAA02006110 DAAA02006111 DAAA02006112
GenPept
ImmGen COL4A4 (murine)
RNA Seq Atlas 101908783 101909787 407107