Version 5.4
Bos taurus Gene: SH3GL1
Summary
InnateDB Gene IDBG-644264.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3GL1
Gene Name Endophilin-A2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006007
Encoded Proteins
IDBP-696899
Endophilin-A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141985:
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:20923762-20951051
Strand Forward strand
Band
Transcripts
ENSBTAT00000007890 ENSBTAP00000007890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0016020 membrane
GO:0030054 cell junction
GO:0031901 early endosome membrane
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000141985
View Gene Order
ENSMUSG00000003200
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt Q2KJA1
TrEMBL
UniProt Splice Variant
Entrez Gene 512719
UniGene Bt.37802
RefSeq NM_001046130 XM_005208933
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105444 BT025352
GenPept AAI05445 ABF57308
RNA Seq Atlas 512719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca