InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.61946

Summary

InnateDB Gene

IDBG-644395.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.61946

Gene Name

V-type proton ATPase subunit H

Synonyms

SFD

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003450

Encoded Proteins

IDBP-697036

V-type proton ATPase subunit H

IDBP-697039

V-type proton ATPase subunit H

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047249:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:23511301-23558678

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004482	ENSBTAP00000004482
ENSBTAT00000004480	ENSBTAP00000004480

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0046961	proton-transporting ATPase activity, rotational mechanism