InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RP1

Summary

InnateDB Gene

IDBG-644419.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RP1

Gene Name

Oxygen-regulated protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011203

Encoded Proteins

IDBP-697055

retinitis pigmentosa 1 (autosomal dominant)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104237:
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:23990193-23999338

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014879

ENSBTAP00000014879

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0035082	axoneme assembly
GO:0035556	intracellular signal transduction
GO:0035845	photoreceptor cell outer segment organization
GO:0042461	photoreceptor cell development
GO:0045494	photoreceptor cell maintenance
GO:0046548	retinal rod cell development
GO:0046549	retinal cone cell development
GO:0060041	retina development in camera-type eye
GO:0060042	retina morphogenesis in camera-type eye
GO:0071482	cellular response to light stimulus

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005875	microtubule associated complex
GO:0005929	cilium
GO:0005930	axoneme
GO:0032391	photoreceptor connecting cilium

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000104237

View Gene Order

ENSMUSG00000025900

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas