Version 5.4
Bos taurus Gene: DIS3L2
Summary
InnateDB Gene IDBG-644453.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIS3L2
Gene Name DIS3-like exonuclease 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011964
Encoded Proteins
IDBP-697101
DIS3 mitotic control homolog (S. cerevisiae)-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144535:
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:120486066-120794558
Strand Forward strand
Band
Transcripts
ENSBTAT00000038112 ENSBTAP00000037928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004540 ribonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0008285 negative regulation of cell proliferation
GO:0010587 miRNA catabolic process
GO:0019827 stem cell maintenance
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0051301 cell division
GO:0051306 mitotic sister chromatid separation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000144535
View Gene Order
ENSMUSG00000053333
View Gene Order
Cross-References
SwissProt
TrEMBL E1B7R0
UniProt Splice Variant
Entrez Gene 519222
UniGene Bt.54653
RefSeq NM_001192506 XM_005202934
HUGO HGNC:28648
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02006206 DAAA02006207 DAAA02006208
GenPept
RNA Seq Atlas 519222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca