Version 5.4
Bos taurus Gene: HDAC1
Summary
InnateDB Gene IDBG-644586.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC1
Gene Name Histone deacetylase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012698
Encoded Proteins
IDBP-697235
Histone deacetylase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:122055992-122087843
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016877 ENSBTAP00000016877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0031078 histone deacetylase activity (H3-K14 specific)
GO:0031492 nucleosomal DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032129 histone deacetylase activity (H3-K9 specific)
GO:0033558 protein deacetylase activity
GO:0033613 activating transcription factor binding
GO:0034739 histone deacetylase activity (H4-K16 specific)
GO:0042826 histone deacetylase binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0008284 positive regulation of cell proliferation
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0032922 circadian regulation of gene expression
GO:0043044 ATP-dependent chromatin remodeling
GO:0043922 negative regulation by host of viral transcription
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_243616
APC truncation mutants have impaired AXIN binding pathway
REACT_226948
G0 and Early G1 pathway
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_221284
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_262425
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_220704
Signaling by NOTCH pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_213874
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_220289
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_215067
Factors involved in megakaryocyte development and platelet production pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_248524
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_221028
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_203419
deactivation of the beta-catenin transactivating complex pathway
REACT_260827
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_226022
Gene Expression pathway
REACT_212196
Hemostasis pathway
REACT_207632
Chromatin organization pathway
REACT_262545
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_248114
HDACs deacetylate histones pathway
REACT_242612
truncations of AMER1 destabilize the destruction complex pathway
REACT_245697
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_211655
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_214934
Cell Cycle pathway
REACT_204419
Signaling by NOTCH1 in Cancer pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_242961
AXIN missense mutants destabilize the destruction complex pathway
REACT_225370
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_214253
NoRC negatively regulates rRNA expression pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_257729
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_225877
Signaling by NOTCH1 pathway
REACT_261055
repression of WNT target genes pathway
REACT_247065
TCF7L2 mutants don't bind CTBP pathway
REACT_223827
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_237056
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_207066
Signalling by NGF pathway
REACT_234401
AMER1 mutants destabilize the destruction complex pathway
REACT_227244
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_215001
Negative epigenetic regulation of rRNA expression pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_225248
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
REACT_204471
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_235327
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_203853
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_222355
formation of the beta-catenin:TCF transactivating complex pathway
REACT_248525
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_203739
Degradation of beta-catenin by the destruction complex pathway
REACT_227044
Chromatin modifying enzymes pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
REACT_263270
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_236276
truncated APC mutants destabilize the destruction complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q32PJ8
TrEMBL Q6RCM7
UniProt Splice Variant
Entrez Gene 404126
UniGene Bt.16500
RefSeq NM_001037444 XM_005202895
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY504948 BC108088 BT030718
GenPept AAI08089 AAR98734 ABS45034
RNA Seq Atlas 404126

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca