InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: P4HA2

Summary

InnateDB Gene

IDBG-644698.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HA2

Gene Name

prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001116

Encoded Proteins

IDBP-697354

prolyl 4-hydroxylase subunit alpha-2 isoform 2

IDBP-697355

prolyl 4-hydroxylase subunit alpha-2 isoform 2

IDBP-697356

prolyl 4-hydroxylase subunit alpha-2 isoform 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072682:
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:23480315-23513315

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064203	ENSBTAP00000056064
ENSBTAT00000001479	ENSBTAP00000001479
ENSBTAT00000001477	ENSBTAP00000001477

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019511	peptidyl-proline hydroxylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000072682

View Gene Order

ENSMUSG00000018906

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00330

Arginine and proline metabolism pathway

mmu00330

Arginine and proline metabolism pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.4381

RefSeq

NM_001034293 NM_001159409 XM_005209035 XM_005209036 XM_005209037 XM_005209038 XM_005209040

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas