Version 5.4
Bos taurus Gene: RAD18
Summary
InnateDB Gene IDBG-644777.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD18
Gene Name E3 ubiquitin-protein ligase RAD18
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012142
Encoded Proteins
IDBP-697446
postreplication repair protein hRAD18p
IDBP-697448
postreplication repair protein hRAD18p
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070950:
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:17627573-17735891
Strand Forward strand
Band
Transcripts
ENSBTAT00000047319 ENSBTAP00000044535
ENSBTAT00000066111 ENSBTAP00000054559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000403 Y-form DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031593 polyubiquitin binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0009411 response to UV
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000785 chromatin
GO:0001741 XY body
GO:0005634 nucleus
GO:0005657 replication fork
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000070950
View Gene Order
ENSMUSG00000030254
View Gene Order
Cross-References
SwissProt
TrEMBL Q32LH8 Q58DB5
UniProt Splice Variant
Entrez Gene 514440
UniGene Bt.26308
RefSeq NM_001035295 XM_005222447
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109568 BT021682 DAAA02053765 DAAA02053766 DAAA02053767 DAAA02053768 DAAA02053769 DAAA02053770
GenPept AAI09569 AAX46529
RNA Seq Atlas 514440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca