InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.29882

Summary

InnateDB Gene

IDBG-644985.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.29882

Gene Name

microphthalmia-associated transcription factor isoform M-

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006679

Encoded Proteins

IDBP-697660

microphthalmia-associated transcription factor isoform M-

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187098:
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:31735990-31769463

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008789

ENSBTAP00000008789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0010468	regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030316	osteoclast differentiation
GO:0030318	melanocyte differentiation
GO:0042127	regulation of cell proliferation
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043473	pigmentation
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045670	regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046849	bone remodeling