InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TPCN2

Summary

InnateDB Gene

IDBG-644999.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPCN2

Gene Name

two pore calcium channel protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015183

Encoded Proteins

IDBP-697685

two pore segment channel 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162341:
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:47037688-47067971

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020205

ENSBTAP00000020205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0072345	NAADP-sensitive calcium-release channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane