InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RRM2B

Summary

InnateDB Gene

IDBG-645071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM2B

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021208

Encoded Proteins

IDBP-697754

ribonucleotide reductase M2 B (TP53 inducible)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000048392:
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:64315460-64352488

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028260

ENSBTAP00000028260

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0016491	oxidoreductase activity

Biological Process

GO:0001822	kidney development
GO:0003014	renal system process
GO:0006264	mitochondrial DNA replication
GO:0006281	DNA repair
GO:0006979	response to oxidative stress
GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009200	deoxyribonucleoside triphosphate metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0055114	oxidation-reduction process
GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator