InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NSD1

Summary

InnateDB Gene

IDBG-645175.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSD1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000025426

Encoded Proteins

IDBP-697867

nuclear receptor binding SET domain protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165671:
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:39982435-40123961

Strand

Forward strand

Band

Transcripts

ENSBTAT00000034204

ENSBTAP00000034104

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0016571	histone methylation
GO:0032259	methylation
GO:0034968	histone lysine methylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000165671

View Gene Order

ENSMUSG00000021488

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

hsa00310

Lysine degradation pathway

mmu00310

Lysine degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BM66

UniProt Splice Variant

Entrez Gene

540197

UniGene

Bt.33266 Bt.91111

RefSeq

XM_002689017 XM_005209162 XM_005209163 XM_005209164 XM_005209165 XM_005209166 XM_005209167

HUGO

HGNC:14234

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02020048 DAAA02020049 DAAA02020050 DAAA02020051

GenPept

RNA Seq Atlas

100336707 540197