Version 5.4
Bos taurus Gene: CDKN1C
Summary
InnateDB Gene IDBG-645186.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDKN1C
Gene Name cyclin-dependent kinase inhibitor 1C
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031184
Encoded Proteins
IDBP-697874
cyclin-dependent kinase inhibitor 1C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129757:
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:49368787-49370785
Strand Forward strand
Band
Transcripts
ENSBTAT00000044159 ENSBTAP00000041672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0016301 kinase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001822 kidney development
GO:0001890 placenta development
GO:0007050 cell cycle arrest
GO:0007568 aging
GO:0016310 phosphorylation
GO:0030099 myeloid cell differentiation
GO:0030325 adrenal gland development
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033673 negative regulation of kinase activity
GO:0035264 multicellular organism growth
GO:0042326 negative regulation of phosphorylation
GO:0042551 neuron maturation
GO:0043010 camera-type eye development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050680 negative regulation of epithelial cell proliferation
GO:0055123 digestive system development
GO:0060065 uterus development
GO:0060669 embryonic placenta morphogenesis
GO:0071514 genetic imprinting
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000129757
View Gene Order
ENSMUSG00000037664
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04110
Cell cycle pathway
mmu04110
Cell cycle pathway
INOH
INOH website
Hedgehog signaling pathway pathway
INOH website
Hedgehog signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1N786 Q2HJM8
UniProt Splice Variant
Entrez Gene 510972
UniGene Bt.4804
RefSeq NM_001077903
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY957984 DAAA02063708
GenPept ABD34312
RNA Seq Atlas 510972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca