Bos taurus Gene: MMP-16
Summary
InnateDB Gene IDBG-645376.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP-16
Gene Name matrix metalloproteinase-16
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006877
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156103:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:76757695-77111545
Strand Forward strand
Band
Transcripts
ENSBTAT00000061368 ENSBTAP00000053634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0001958 endochondral ossification
GO:0006508 proteolysis
GO:0030574 collagen catabolic process
GO:0035988 chondrocyte proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060348 bone development
GO:0097094 craniofacial suture morphogenesis
Cellular Component
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Activation of Matrix Metalloproteinases pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N797 Q9XSI9
UniProt Splice Variant
Entrez Gene 282886
UniGene Bt.13089
RefSeq NM_001192622
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF144760 DAAA02039538 DAAA02039539 DAAA02039540 DAAA02039541 DAAA02039542
GenPept AAD30300
RNA Seq Atlas 282886