Version 5.4
| Bos taurus Gene: WWP1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-645403.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | WWP1 | ||||||||
| Gene Name | NEDD4-like E3 ubiquitin-protein ligase WWP1 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000015720 | ||||||||
| Encoded Proteins |
NEDD4-like E3 ubiquitin-protein ligase WWP1
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123124:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 14:78599363-78699784 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
TGF_beta_Receptor pathway
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| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Stimuli-sensing channels pathway
Downregulation of ERBB4 signaling pathway
Signaling by ERBB4 pathway
Transmembrane transport of small molecules pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Ion channel transport pathway
Class I MHC mediated antigen processing & presentation pathway
Stimuli-sensing channels pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by ERBB4 pathway
Immune System pathway
Downregulation of ERBB4 signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
Adaptive Immune System pathway
Signal Transduction pathway
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| KEGG |
Ubiquitin mediated proteolysis pathway
Endocytosis pathway
Ubiquitin mediated proteolysis pathway
Endocytosis pathway
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| INOH | |||||||||
| PID NCI |
ErbB4 signaling events
TGF-beta receptor signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.14630 Bt.89307 | ||||||||
| RefSeq | NM_001037463 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||