Bos taurus Gene: MAP2K5 | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||
InnateDB Gene | IDBG-645481.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | MAP2K5 | ||||||||||||||||
Gene Name | dual specificity mitogen-activated protein kinase kinase 5 | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000000218 | ||||||||||||||||
Encoded Proteins |
mitogen-activated protein kinase kinase 5
|
||||||||||||||||
Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137764:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011] |
||||||||||||||||
Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 10:14354690-14626128 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
|
||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
|
||||||||||||||||
Gene Ontology | |||||||||||||||||
Molecular Function |
|
||||||||||||||||
Biological Process |
|
||||||||||||||||
Cellular Component |
|
||||||||||||||||
Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
EGFR1 pathway
TNFalpha pathway
|
||||||||||||||||
REACTOME |
Signalling to ERK5 pathway
Signalling by NGF pathway
Signal Transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Signalling to ERK5 pathway
Signalling by NGF pathway
NGF signalling via TRKA from the plasma membrane pathway
Signal Transduction pathway
|
||||||||||||||||
KEGG |
Gap junction pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
Gap junction pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
|
||||||||||||||||
INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
|
||||||||||||||||
PID NCI |
Trk receptor signaling mediated by the MAPK pathway
ErbB1 downstream signaling
|
||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | E1BI01 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 100295732 | ||||||||||||||||
UniGene | Bt.38334 Bt.49194 | ||||||||||||||||
RefSeq | NM_001206770 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02027915 DAAA02027916 DAAA02027917 DAAA02027918 DAAA02027919 DAAA02027920 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 100295732 | ||||||||||||||||