Version 5.4
Bos taurus Gene: ITIH3
Summary
InnateDB Gene IDBG-645484.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH3
Gene Name Inter-alpha-trypsin inhibitor heavy chain H3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007846
Encoded Proteins
IDBP-698189
Inter-alpha-trypsin inhibitor heavy chain H3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162267:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:48633831-48647777
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010322 ENSBTAP00000010322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162267
View Gene Order
ENSMUSG00000006522
View Gene Order
Cross-References
SwissProt P56652
TrEMBL
UniProt Splice Variant
Entrez Gene 508355
UniGene Bt.21243
RefSeq NM_001101898 XM_005222754
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151419 BT026189
GenPept AAI51420 ABG67028
RNA Seq Atlas 508355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca