Homo sapiens Gene: NEU3
Summary
InnateDB Gene IDBG-64552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEU3
Gene Name sialidase 3 (membrane sialidase)
Synonyms SIAL3;
Species Homo sapiens
Ensembl Gene ENSG00000162139
Encoded Proteins
sialidase 3 (membrane sialidase)
sialidase 3 (membrane sialidase)
sialidase 3 (membrane sialidase)
sialidase 3 (membrane sialidase)
sialidase 3 (membrane sialidase)
sialidase 3 (membrane sialidase)
sialidase 3 (membrane sialidase)
Protein Structure
Entrez Gene
Summary This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74988134-75018893
Strand Forward strand
Band q13.4
Transcripts
ENST00000294064 ENSP00000294064
ENST00000531509 ENSP00000432097
ENST00000529024 ENSP00000434474
ENST00000526068 ENSP00000436540
ENST00000532963 ENSP00000434907
ENST00000531619 ENSP00000436118
ENST00000534628 ENSP00000434754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004308 exo-alpha-sialidase activity
GO:0016997 alpha-sialidase activity
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006689 ganglioside catabolic process
GO:0008152 metabolic process
GO:0009313 oligosaccharide catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
Glycosphingolipid metabolism pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Metabolism pathway
KEGG
Other glycan degradation pathway
Sphingolipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UQ49
TrEMBL A0A024R5N6 B4E0V4 E9PI40 E9PMZ3 E9PNK1 E9PR25
UniProt Splice Variant
Entrez Gene 10825
UniGene Hs.191074 Hs.606201
RefSeq NM_006656
HUGO HGNC:7760
OMIM 604617
CCDS CCDS44682
HPRD 05215
IMGT
EMBL AB008185 AK022450 AK290442 AK303540 AP001992 BC136397 BC144059 CH471076 Y18563
GenPept AAI36398 AAI44060 BAA82611 BAF83131 BAG51074 BAG64566 CAB96131 EAW74953 EAW74954
ImmGen NEU3 (murine)
RNA Seq Atlas 10825