InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ELA2

Summary

InnateDB Gene

IDBG-645525.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELA2

Gene Name

neutrophil elastase precursor

Synonyms

ELA2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046188

Encoded Proteins

IDBP-698237

neutrophil elastase

IDBP-698238

neutrophil elastase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18772136

[Homo sapiens] ELANE is a pro-inflammatory protease that regulates IL8 production from airway epithelial cells and can activate both EGFR and TLR4.

PMID 18802098

[Homo sapiens] ELANE mediates innate host protection against Pseudomonas aeruginosa by degrading the major outer membrane protein F, a protein involved in porin activity, maintenance of structural integrity, and sensing of host immune system activation.

PMID 20676107

[Homo sapiens] ELANE and CTSG, together with externalized nucleosomes, promote coagulation and intravascular thrombus growth in vivo. During systemic infection, activation of coagulation fosters compartmentalization of bacteria in liver microvessels and reduces bacterial invasion into tissue.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197561:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein\'s release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44988172-44991299

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064480	ENSBTAP00000053944
ENSBTAT00000063577	ENSBTAP00000055933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0002020	protease binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0019955	cytokine binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001878	response to yeast
GO:0002438	acute inflammatory response to antigenic stimulus
GO:0006508	proteolysis
GO:0006909	phagocytosis
GO:0009411	response to UV
GO:0032496	response to lipopolysaccharide
GO:0042742	defense response to bacterium
GO:0044130	negative regulation of growth of symbiont in host
GO:0045079	negative regulation of chemokine biosynthetic process
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050778	positive regulation of immune response
GO:0050832	defense response to fungus
GO:0050900	leukocyte migration
GO:0070947	neutrophil mediated killing of fungus

Cellular Component

GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0017053	transcriptional repressor complex
GO:0030141	secretory granule
GO:0070062	extracellular vesicular exosome