Version 5.4
| Bos taurus Gene: SIGIRR | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-645604.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | SIGIRR | ||||||||||
| Gene Name | single Ig IL-1-related receptor | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000011149 | ||||||||||
| Encoded Proteins |
single Ig IL-1-related receptor
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] SIGIRR is a negative modulator of TLR-IL-1R signalling where it binds to the TLR-IL-1R signalling components in a ligand-dependent way.
[Homo sapiens] SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signalling pathway.
[Homo sapiens] SIGIRR regulates innate responses in differentiated human intestinal epithelial cells (IECs), modulating epithelial involvement in infectious and inflammatory bowel diseases.
[Homo sapiens] SIGIRR can inhibit Toll-like receptor (TLR) 4, 5, and 9-mediated immune responses by attenuating production of the inflammatory mediators IL-6 and TNF-alpha and this attenuation was not the result of decreased expression of TLR4, 5 or 9, but rather a sequestration of MYD88 to the TLRs.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185187:
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 29:51265567-51271520 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Immune System pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | A2VDZ6 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 531801 | ||||||||||
| UniGene | Bt.54900 | ||||||||||
| RefSeq | NM_001082443 XM_005227364 XM_005227366 XM_005227367 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC133493 DAAA02063788 | ||||||||||
| GenPept | AAI33494 | ||||||||||
| RNA Seq Atlas | 531801 | ||||||||||