InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GAMT

Summary

InnateDB Gene

IDBG-645635.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAMT

Gene Name

Guanidinoacetate N-methyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004112

Encoded Proteins

IDBP-698355

Guanidinoacetate N-methyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130005:
The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45433859-45436865

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005375

ENSBTAP00000005375

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0016740	transferase activity
GO:0030731	guanidinoacetate N-methyltransferase activity

Biological Process

GO:0006601	creatine biosynthetic process
GO:0007283	spermatogenesis
GO:0009887	organ morphogenesis
GO:0032259	methylation
GO:0040014	regulation of multicellular organism growth