InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GNAT1

Summary

InnateDB Gene

IDBG-645840.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAT1

Gene Name

Guanine nucleotide-binding protein G(t) subunit alpha-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018020

Encoded Proteins

IDBP-698594

Guanine nucleotide-binding protein G(t) subunit alpha-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114349:
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:50723440-50728454

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023990

ENSBTAP00000023990

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000035	acyl binding
GO:0000166	nucleotide binding
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0019901	protein kinase binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0007603	phototransduction, visible light
GO:0008283	cell proliferation
GO:0009416	response to light stimulus
GO:0042462	eye photoreceptor cell development
GO:0050896	response to stimulus
GO:0050908	detection of light stimulus involved in visual perception
GO:0050917	sensory perception of umami taste
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0060041	retina development in camera-type eye
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005834	heterotrimeric G-protein complex
GO:0032391	photoreceptor connecting cilium
GO:0042622	photoreceptor outer segment membrane
GO:0097381	photoreceptor disc membrane