InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.41304

Summary

InnateDB Gene

IDBG-646220.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.41304

Gene Name

parathyroid hormone/parathyroid hormone-related peptide receptor precursor

Synonyms

PTHR1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016948

Encoded Proteins

IDBP-699002

parathyroid hormone/parathyroid hormone-related peptide receptor precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160801:
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen\'s metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:53161302-53224114

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022555

ENSBTAP00000022555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004991	parathyroid hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0043621	protein self-association

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0002062	chondrocyte differentiation
GO:0002076	osteoblast development
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0030282	bone mineralization
GO:0045453	bone resorption
GO:0048469	cell maturation

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome