InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCK2

Summary

InnateDB Gene

IDBG-64634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCK2

Gene Name

NCK adaptor protein 2

Synonyms

GRB4; NCKbeta

Species

Homo sapiens

Ensembl Gene

ENSG00000071051

Encoded Proteins

IDBP-64636

NCK adaptor protein 2

IDBP-243807

NCK adaptor protein 2

IDBP-243809

NCK adaptor protein 2

IDBP-384093

NCK adaptor protein 2

IDBP-384094

NCK adaptor protein 2

IDBP-475004

NCK adaptor protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:105744897-105894274

Strand

Forward strand

Band

q12.2

Transcripts

ENST00000233154	ENSP00000233154
ENST00000393349	ENSP00000377018
ENST00000393348	ENSP00000377017
ENST00000451463	ENSP00000410428
ENST00000425756	ENSP00000408040
ENST00000522586	ENSP00000431109

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0030159	receptor signaling complex scaffold activity

Biological Process

GO:0006417	regulation of translation
GO:0007015	actin filament organization
GO:0007165	signal transduction
GO:0007172	signal complex assembly
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0030838	positive regulation of actin filament polymerization
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter