InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL12B

Summary

InnateDB Gene

IDBG-646420.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL12B

Gene Name

Interleukin-12 subunit beta

Synonyms

IL12p40

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004741

Encoded Proteins

IDBP-699226

Interleukin-12 subunit beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20145200

[Homo sapiens] IL12B production in response to Toll-like receptor (TLR) stimulation is regulated by the tyrosine phosphatase activity of PTPN6 and this is a novel mechanism for host regulation of IL12, a cytokine important in both innate and adaptive immunity.

PMID 20935648

[Homo sapiens] IL12, consisting of IL12A and IL12B subunits, initiates local antitumor immunity by stimulating lymphoid tissue-inducer (LTi) cells bearing the natural cytotoxicity receptor NCR1 (NKp46).

PMID 22888135

[Homo sapiens] IL12, consisting of IL12A and IL12B subunits, induces IL2RA to form high-affinity IL2 receptors on natural killer cells in response to mouse cytomegalovirus infection. (Demonstrated in mouse)

PMID 23990628

[Homo sapiens] Macrophages cultured with bile acids produce lower levels of IL12 and display an anti-inflammatory phenotype characterized by an increased ratio of IL10 to IL12

PMID 24012417

[Homo sapiens] IFN gamma creates a primed chromatin environment in macrophages to augment TLR-induced IL12B transcription

PMID 22888135

[Mus musculus] Il12, consisting of Il12a and Il12b subunits, induces Il2ra to form high-affinity Il2 receptors on natural killer cells in response to mouse cytomegalovirus infection.

PMID 24163408

[Mus musculus] Nod1 and Nod2 synergize with Tlr4 in dendritic cells to increase IL12 production and enhance invariant natural killer T (iNKT) cell activation, and are important regulators of the IFN gamma response by iNKT cells during S. typhimurium and L. monocytogenes infections.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113302:
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:73006707-73017100

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006222

ENSBTAP00000006222

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042164	interleukin-12 alpha subunit binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0045519	interleukin-23 receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0007050	cell cycle arrest
GO:0007166	cell surface receptor signaling pathway
GO:0010224	response to UV-B
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0016477	cell migration
GO:0019221	cytokine-mediated signaling pathway
GO:0030101	natural killer cell activation
GO:0032693	negative regulation of interleukin-10 production
GO:0032700	negative regulation of interleukin-17 production
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032816	positive regulation of natural killer cell activation
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0042093	T-helper cell differentiation
GO:0042095	interferon-gamma biosynthetic process
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832	defense response to protozoan
GO:0044130	negative regulation of growth of symbiont in host
GO:0045672	positive regulation of osteoclast differentiation
GO:0045785	positive regulation of cell adhesion
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050829	defense response to Gram-negative bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0051142	positive regulation of NK T cell proliferation
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043514	interleukin-12 complex
GO:0070743	interleukin-23 complex