InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZFYVE16

Summary

InnateDB Gene

IDBG-646473.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFYVE16

Gene Name

zinc finger FYVE domain-containing protein 16

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021577

Encoded Proteins

IDBP-699287

zinc finger, FYVE domain containing 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000039319:
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004 [PubMed 14613930]).[supplied by OMIM, Mar 2008]
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:82875305-82908670

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028751

ENSBTAP00000028751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008565	protein transporter activity
GO:0046872	metal ion binding