InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTGDR

Summary

InnateDB Gene

IDBG-646476.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGDR

Gene Name

Prostaglandin D2 receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006703

Encoded Proteins

IDBP-699285

Prostaglandin D2 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168229:
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. [provided by RefSeq, Jul 2008]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:45205473-45212956

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008808

ENSBTAP00000008808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001785	prostaglandin J receptor activity
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004956	prostaglandin D receptor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030238	male sex determination
GO:0030431	sleep
GO:0046085	adenosine metabolic process
GO:0071799	cellular response to prostaglandin D stimulus