Version 5.4
| Bos taurus Gene: CCNH | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-646531.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CCNH | ||||||||
| Gene Name | cyclin-H | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000009566 | ||||||||
| Encoded Proteins |
cyclin-H
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134480:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 7:89393228-89423692 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
AndrogenReceptor pathway
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| REACTOME |
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Cyclin D associated events in G1 pathway
Cyclin A/B1 associated events during G2/M transition pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase I Transcription Initiation pathway
mRNA Capping pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
HIV Transcription Initiation pathway
RNA Polymerase II HIV Promoter Escape pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Dual incision reaction in GG-NER pathway
Formation of incision complex in GG-NER pathway
G1 Phase pathway
RNA Polymerase I Transcription pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Global Genomic NER (GG-NER) pathway
G1/S Transition pathway
Cell Cycle pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
HIV Life Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Mitotic G2-G2/M phases pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
Transcription-coupled NER (TC-NER) pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Formation of the Early Elongation Complex pathway
G1 Phase pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in GG-NER pathway
RNA Polymerase II Transcription Initiation pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
RNA Polymerase II Promoter Escape pathway
Global Genomic NER (GG-NER) pathway
Formation of incision complex in GG-NER pathway
RNA Polymerase I Transcription Termination pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
Cyclin D associated events in G1 pathway
DNA Repair pathway
Mitotic G2-G2/M phases pathway
RNA Polymerase II Transcription Elongation pathway
Cyclin A/B1 associated events during G2/M transition pathway
G1/S Transition pathway
RNA Polymerase II Pre-transcription Events pathway
Mitotic G1-G1/S phases pathway
mRNA Capping pathway
Gene Expression pathway
RNA Polymerase I Promoter Escape pathway
Cyclin E associated events during G1/S transition pathway
Dual incision reaction in TC-NER pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase II Transcription pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
S Phase pathway
RNA Polymerase I Transcription Initiation pathway
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| KEGG |
Cell cycle pathway
Basal transcription factors pathway
Nucleotide excision repair pathway
Basal transcription factors pathway
Cell cycle pathway
Nucleotide excision repair pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI |
Retinoic acid receptors-mediated signaling
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | |||||||||
| RefSeq | NM_001079788 XM_005209735 XM_005209736 XM_005209738 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||