Bos taurus Gene: CA12
Summary
InnateDB Gene IDBG-646532.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA12
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019390
Encoded Proteins
carbonic anhydrase XII
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074410:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10%% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:46749740-46768704
Strand Forward strand
Band
Transcripts
ENSBTAT00000025837 ENSBTAP00000025837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006730 one-carbon metabolic process
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Reversible hydration of carbon dioxide pathway
Metabolism pathway
Metabolism pathway
Reversible hydration of carbon dioxide pathway
KEGG
Nitrogen metabolism pathway
Nitrogen metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MPL2
UniProt Splice Variant
Entrez Gene 614323
UniGene
RefSeq XM_005193642 XM_005193643 XM_005211744 XM_005211745
HUGO HGNC:1371
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028748 DAAA02028749
GenPept
RNA Seq Atlas 614323