InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RORA

Summary

InnateDB Gene

IDBG-646570.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RORA

Gene Name

nuclear receptor ROR-alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015904

Encoded Proteins

IDBP-699388

RAR-related orphan receptor A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22267218

[Homo sapiens] The transcription factor RORA is critical for the development of nuocytes and the mounting of innate type 2 immunity against parasitic worms. (Demonstrated in mice)

PMID 22267218

[Mus musculus] The transcription factor Rora is critical for the development of nuocytes and the mounting of innate type 2 immunity against parasitic worms.

PMID 26045547

[Mus musculus] Nlrp3 is a novel molecular target for melatonin which requires Rora to blunt the NFkB/ NLRP3 connection during sepsis.

Entrez Gene

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:48949618-49750993

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021144

ENSBTAP00000021144

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001222	transcription corepressor binding
GO:0001223	transcription coactivator binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008142	oxysterol binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0098531	direct ligand regulated sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0008589	regulation of smoothened signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010906	regulation of glucose metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021930	cerebellar granule cell precursor proliferation
GO:0030522	intracellular receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0036315	cellular response to sterol
GO:0042692	muscle cell differentiation
GO:0042752	regulation of circadian rhythm
GO:0042753	positive regulation of circadian rhythm
GO:0043030	regulation of macrophage activation
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401	steroid hormone mediated signaling pathway
GO:0045599	negative regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046068	cGMP metabolic process
GO:0050728	negative regulation of inflammatory response
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0070328	triglyceride homeostasis
GO:0071456	cellular response to hypoxia
GO:0072539	T-helper 17 cell differentiation
GO:2000188	regulation of cholesterol homeostasis