Version 5.4
| Bos taurus Gene: CAST | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-646586.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CAST | ||||||||
| Gene Name | calpastatin isoform I | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000000874 | ||||||||
| Encoded Proteins |
calpastatin isoform I
calpastatin isoform I
calpastatin isoform I
calpastatin isoform I
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153113:
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 7:98444979-98581253 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | A4GVW8 F1MD74 F1MR96 F1N161 G3N2N7 Q52ZH1 Q52ZH2 Q52ZH3 Q9GL38 Q9MYX9 Q9TV94 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 281039 | ||||||||
| UniGene | Bt.4738 | ||||||||
| RefSeq | NM_001030318 NM_001030319 NM_001030320 NM_174003 XM_005209743 XM_005209745 XM_005209747 XM_005209748 XM_005209749 XM_005209750 XM_005209751 XM_005209752 XM_005209753 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF117813 AF281256 AY008267 AY834761 AY834762 AY834763 DAAA02021346 DAAA02021347 DAAA02021348 DAAA02021349 DAAA02021350 DAAA02021351 EF443057 EF443058 EF443059 | ||||||||
| GenPept | AAD21054 AAF88058 AAG23869 AAV88515 AAV88516 AAV88517 ABO31107 ABO31108 ABO31109 | ||||||||
| RNA Seq Atlas | 281039 | ||||||||