Version 5.4
| Bos taurus Gene: FGF7 | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-646673.3 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | FGF7 | ||||||||||||||||||||||||||||||
| Gene Name | keratinocyte growth factor precursor | ||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000004013 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
fibroblast growth factor 7
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| Protein Structure | |||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] FGF7 enhances alveolar host defence through GM-CSF-stimulated macrophage activation. Intrapulmonary FGF7 injection enhanced the clearance of E. coli or P. aeruginosa via the augmented recruitment, phagocytic activity and oxidant responses of macrophages. (Demonstrated in murine model)
[Mus musculus] Fgf7 enhances alveolar host defence through GM-CSF-stimulated macrophage activation. Intrapulmonary Fgf7 injection enhanced the clearance of E. coli or P. aeruginosa via the augmented recruitment, phagocytic activity and oxidant responses of macrophages.
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| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140285:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 10:61005653-61068184 | ||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Negative regulation of FGFR signaling pathway
Phospholipase C-mediated cascade pathway
SHC-mediated cascade pathway
PI-3K cascade pathway
FRS2-mediated cascade pathway
FGFR2b ligand binding and activation pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activated point mutants of FGFR2 pathway
Signaling by FGFR mutants pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Signaling by Insulin receptor pathway
FGFR2b ligand binding and activation pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
FGFR2 ligand binding and activation pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Negative regulation of FGFR signaling pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
FGFR ligand binding and activation pathway
Signaling by EGFR pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Phospholipase C-mediated cascade pathway
PI3K Cascade pathway
Signaling by FGFR2 mutants pathway
Activated point mutants of FGFR2 pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR mutants pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
SHC-mediated cascade pathway
GAB1 signalosome pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Melanoma pathway
Pathways in cancer pathway
Melanoma pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Pathways in cancer pathway
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| INOH |
FGF signaling pathway pathway
GPCR signaling pathway
FGF signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Glypican 3 network
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| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||
| TrEMBL | E1BEB9 | ||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | 616885 | ||||||||||||||||||||||||||||||
| UniGene | Bt.30726 | ||||||||||||||||||||||||||||||
| RefSeq | NM_001193131 XM_005211861 | ||||||||||||||||||||||||||||||
| HUGO | HGNC:3685 | ||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| EMBL | DAAA02029101 DAAA02029102 DAAA02029103 DAAA02029104 | ||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||
| RNA Seq Atlas | 616885 | ||||||||||||||||||||||||||||||