Version 5.4
Bos taurus Gene: SORD
Summary
InnateDB Gene IDBG-646701.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORD
Gene Name Sorbitol dehydrogenase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025496
Encoded Proteins
IDBP-699528
Sorbitol dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140263:
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:65575408-65609640
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035849 ENSBTAP00000035716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003939 L-iditol 2-dehydrogenase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006060 sorbitol metabolic process
GO:0006062 sorbitol catabolic process
GO:0030317 sperm motility
GO:0046370 fructose biosynthetic process
GO:0051160 L-xylitol catabolic process
GO:0051164 L-xylitol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005929 cilium
GO:0016020 membrane
GO:0031514 motile cilium
GO:0031966 mitochondrial membrane
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000140263
View Gene Order
ENSMUSG00000027227
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00040
Pentose and glucuronate interconversions pathway
hsa00051
Fructose and mannose metabolism pathway
mmu00051
Fructose and mannose metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt Q58D31
TrEMBL
UniProt Splice Variant
Entrez Gene 508954
UniGene Bt.16122
RefSeq NM_001037320
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122783 BT021766
GenPept AAI22784 AAX46613
RNA Seq Atlas 508954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca