InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BMP4

Summary

InnateDB Gene

IDBG-646706.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP4

Gene Name

Bone morphogenetic protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003835

Encoded Proteins

IDBP-699534

Bone morphogenetic protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125378:
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5\' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:66751296-66755026

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004992

ENSBTAP00000004992

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity
GO:0070700	BMP receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000186	activation of MAPKK activity
GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001649	osteoblast differentiation
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001707	mesoderm formation
GO:0001759	organ induction
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0001843	neural tube closure
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001944	vasculature development
GO:0001958	endochondral ossification
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062	chondrocyte differentiation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002320	lymphoid progenitor cell differentiation
GO:0003014	renal system process
GO:0003130	BMP signaling pathway involved in heart induction
GO:0003139	secondary heart field specification
GO:0003323	type B pancreatic cell development
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007224	smoothened signaling pathway
GO:0007275	multicellular organismal development
GO:0007281	germ cell development
GO:0007500	mesodermal cell fate determination
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0009888	tissue development
GO:0009948	anterior/posterior axis specification
GO:0010159	specification of organ position
GO:0010453	regulation of cell fate commitment
GO:0010468	regulation of gene expression
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942	positive regulation of cell death
GO:0021537	telencephalon development
GO:0021904	dorsal/ventral neural tube patterning
GO:0021978	telencephalon regionalization
GO:0021983	pituitary gland development
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030224	monocyte differentiation
GO:0030225	macrophage differentiation
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0032092	positive regulation of protein binding
GO:0032331	negative regulation of chondrocyte differentiation
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0033088	negative regulation of immature T cell proliferation in thymus
GO:0034504	protein localization to nucleus
GO:0035116	embryonic hindlimb morphogenesis
GO:0035990	tendon cell differentiation
GO:0035993	deltoid tuberosity development
GO:0040007	growth
GO:0042326	negative regulation of phosphorylation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042476	odontogenesis
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0043010	camera-type eye development
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0045165	cell fate commitment
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045606	positive regulation of epidermal cell differentiation
GO:0045662	negative regulation of myoblast differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045786	negative regulation of cell cycle
GO:0045839	negative regulation of mitosis
GO:0045843	negative regulation of striated muscle tissue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048286	lung alveolus development
GO:0048333	mesodermal cell differentiation
GO:0048392	intermediate mesodermal cell differentiation
GO:0048593	camera-type eye morphogenesis
GO:0048598	embryonic morphogenesis
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048660	regulation of smooth muscle cell proliferation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048663	neuron fate commitment
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048745	smooth muscle tissue development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050918	positive chemotaxis
GO:0051145	smooth muscle cell differentiation
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051216	cartilage development
GO:0055020	positive regulation of cardiac muscle fiber development
GO:0060113	inner ear receptor cell differentiation
GO:0060197	cloacal septation
GO:0060235	lens induction in camera-type eye
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060348	bone development
GO:0060363	cranial suture morphogenesis
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395	SMAD protein signal transduction
GO:0060425	lung morphogenesis
GO:0060429	epithelium development
GO:0060433	bronchus development
GO:0060438	trachea development
GO:0060440	trachea formation
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060449	bud elongation involved in lung branching
GO:0060502	epithelial cell proliferation involved in lung morphogenesis
GO:0060503	bud dilation involved in lung branching
GO:0060512	prostate gland morphogenesis
GO:0060548	negative regulation of cell death
GO:0060592	mammary gland formation
GO:0060684	epithelial-mesenchymal cell signaling
GO:0060686	negative regulation of prostatic bud formation
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060688	regulation of morphogenesis of a branching structure
GO:0061035	regulation of cartilage development
GO:0061036	positive regulation of cartilage development
GO:0061047	positive regulation of branching involved in lung morphogenesis
GO:0061149	BMP signaling pathway involved in ureter morphogenesis
GO:0061151	BMP signaling pathway involved in renal system segmentation
GO:0061155	pulmonary artery endothelial tube morphogenesis
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071893	BMP signaling pathway involved in nephric duct formation
GO:0072001	renal system development
GO:0072015	glomerular visceral epithelial cell development
GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104	glomerular capillary formation
GO:0072125	negative regulation of glomerular mesangial cell proliferation
GO:0072138	mesenchymal cell proliferation involved in ureteric bud development
GO:0072161	mesenchymal cell differentiation involved in kidney development
GO:0072192	ureter epithelial cell differentiation
GO:0072193	ureter smooth muscle cell differentiation
GO:0072198	mesenchymal cell proliferation involved in ureter development
GO:0072200	negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205	metanephric collecting duct development
GO:0090184	positive regulation of kidney development
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194	negative regulation of glomerulus development
GO:2000005	negative regulation of metanephric S-shaped body morphogenesis
GO:2000007	negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105	positive regulation of DNA-dependent DNA replication
GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012	mesenchymal cell differentiation involved in renal system development