Version 5.4
Bos taurus Gene: SIX1
Summary
InnateDB Gene IDBG-646750.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIX1
Gene Name SIX1 protein; Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012139
Encoded Proteins
IDBP-699581
SIX1 proteinUncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126778:
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila \'sine oculis\' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:73068706-73072802
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016104 ENSBTAP00000016104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001822 kidney development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007389 pattern specification process
GO:0007519 skeletal muscle tissue development
GO:0030855 epithelial cell differentiation
GO:0030878 thyroid gland development
GO:0042472 inner ear morphogenesis
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048538 thymus development
GO:0048699 generation of neurons
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048839 inner ear development
GO:0051451 myoblast migration
GO:0072075 metanephric mesenchyme development
GO:0072095 regulation of branch elongation involved in ureteric bud branching
GO:0072107 positive regulation of ureteric bud formation
GO:0072172 mesonephric tubule formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000126778
View Gene Order
ENSMUSG00000051367
View Gene Order
Cross-References
SwissProt
TrEMBL Q08DI4
UniProt Splice Variant
Entrez Gene 511371
UniGene Bt.47753
RefSeq XM_002691019 XM_588692
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123733 DAAA02029309
GenPept AAI23734
RNA Seq Atlas 511371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca