InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNH5

Summary

InnateDB Gene

IDBG-646761.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH5

Gene Name

potassium voltage-gated channel subfamily H member 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011379

Encoded Proteins

IDBP-699592

potassium voltage-gated channel, subfamily H (eag-related), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140015:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:75235434-75637242

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015122

ENSBTAP00000015122

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0023014	signal transduction by phosphorylation
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000140015

View Gene Order

ENSMUSG00000034402

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199077

Voltage gated Potassium channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MP51

UniProt Splice Variant

Entrez Gene

537813

UniGene

Bt.99276

RefSeq

NM_001192989

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02029358 DAAA02029359 DAAA02029360 DAAA02029361 DAAA02029362 DAAA02029363 DAAA02029364 DAAA02029365 DAAA02029366 DAAA02029367 DAAA02029368 DAAA02029369 DAAA02029370 DAAA02029371 DAAA02029372 DAAA02029373 DAAA02029374 DAAA02029375 DAAA02029376 DAAA02029377 DAAA02029378

GenPept

RNA Seq Atlas

537813