InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6V1D

Summary

InnateDB Gene

IDBG-646787.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1D

Gene Name

V-type proton ATPase subunit D

Synonyms

VATD

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016309

Encoded Proteins

IDBP-699621

V-type proton ATPase subunit D

IDBP-699622

V-type proton ATPase subunit D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100554:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:79584175-79599910

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021699	ENSBTAP00000021699
ENSBTAT00000056016	ENSBTAP00000050203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0042384	cilium assembly
GO:0055085	transmembrane transport
GO:0061512	protein localization to cilium

Cellular Component

GO:0005765	lysosomal membrane
GO:0005813	centrosome
GO:0005929	cilium
GO:0016020	membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0070062	extracellular vesicular exosome