InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.64612

Summary

InnateDB Gene

IDBG-646834.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64612

Gene Name

protein numb homolog

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011683

Encoded Proteins

IDBP-699671

protein numb homolog

IDBP-699672

protein numb homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24092752

[Mus musculus] Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133961:
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:85126907-85183835

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000052258	ENSBTAP00000052600
ENSBTAT00000015508	ENSBTAP00000015508

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding

Biological Process

GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007409	axonogenesis
GO:0021670	lateral ventricle development
GO:0021849	neuroblast division in subventricular zone
GO:0030862	positive regulation of polarized epithelial cell differentiation
GO:0030900	forebrain development
GO:0034332	adherens junction organization
GO:0045746	negative regulation of Notch signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0060487	lung epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0016323	basolateral plasma membrane
GO:0019897	extrinsic component of plasma membrane
GO:0045177	apical part of cell