Version 5.4
Bos taurus Gene: FFAR1
Summary
InnateDB Gene IDBG-647184.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FFAR1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000045806
Encoded Proteins
IDBP-700032
free fatty acid receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126266:
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:46243828-46244730
Strand Forward strand
Band
Transcripts
ENSBTAT00000063172 ENSBTAP00000055089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030073 insulin secretion
GO:0042593 glucose homeostasis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000126266
View Gene Order
ENSMUSG00000044453
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_21268
Free fatty acid receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_23824
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_19193
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_19375
Free fatty acids regulate insulin secretion pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_258788
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_223625
GPCR downstream signaling pathway
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_259776
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_231468
GPCR ligand binding pathway
REACT_198709
Free fatty acid receptors pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_251998
Free fatty acids regulate insulin secretion pathway
REACT_253751
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3MZT6
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:4498
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046939
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca